Type 1 and 5 secretion systems and associated toxins - Escherichia coli: Pathotypes and Principles of Pathogenesis - page 500

TABLE 16.1 Type 5 secreted proteins of E. coli

Pathotypes
predominantly
associated with
the protein

Characterized
virulence
properties Protein Reference

AT

SPATES

EatA ETEC Serine protease

activity

( Patel et al., 2004 )

EpeA EAEC Protease and

mucinase activity

( Leyton et al., 2003 )

EspC EPEC Enterotoxin ( Stein et al., 1996;

Mellies et al., 2001 )

EspP EHEC Proteolytic toxin ( Brunder et al.,

1997; Djafari et al.,
1997 )

Pet EAEC Proteolytic toxin ( Eslava et al., 1998 )

PicU UPEC Mucinase ( Parham et al., 2004 )

RpeA EPEC Colonization

factor

( Leyton et al., 2007 )

Sat UPEC Proteolytic toxin ( Guyer et al., 2000,

2002 )

Tsh APEC (Avian

pathogenic
E. coli )

Hemagglutinin/
hemoglobin binding

( Provence & Curtiss,
1994 ; Otto et al.,
1998 )

AIDA-I type
AatA APEC Adhesion to

chicken embryo
fibroblast cells,
contribution to
APEC virulence

( Li et al., 2009 )

AIDA-I EAEC Adhesion,

autoaggregation,
bioilm formation,
self-recognition

( Benz and Schmidt,
1989; Sherlock
et al., 2004 )

Ag43 Widespread Biofilm formation,

autoaggregation,
self-recognition,
phase variable

( Kjaergaard et al.,
2000b; Torres et al.,
2002; Klemm et al.,
2004; Ulett et al.,
2006 )