Type 3 secretion effectors - Escherichia coli: Pathotypes and Principles of Pathogenesis - page 448

IpgD Invasion - phosphoino-

sitide signaling
Inhibits apoptosis -
degradation of p53

PtdIns(4,5)P(2)
( Niebuhr et al., 2002 )

SopB 1 1 1 1

VirA Cytoskeletal remodeling

- MT
Inhibits apoptosis -
degradation of p53

Tubulin ( Yoshida
et al., 2002 )

EspG 1 1 1 1

IcsB Immunomodulation -

escape from autophagy

Cholesterol ( Kayath
et al., 2010 )

BopA 1 1 1 1

OspB Immunomodulation -

inhibits polymorphonuclear
(PMN) migration, MAPK
signaling

Retinoblastoma (Rb)
( Zurawski et al.,
2009 )

- 1 1 1 1

OspC Immunomodulation -

inhibits PMN migration

- - 3(1) b 4 3(1) 3(1)

OspD Unknown - EspL 3 3 3 3

OspE Cell integrity - maintains

focal adhesions

Integrin-linked kinase
( Kim et al., 2009 )

EspO 1 2 1 1(1)

OspF Immunomodulation -

dephosphorylates MAPK,
reduces PMN migration

MAPK (ERK2) ( Li et al.,
2007 ), b-tubulin, Rb
( Zurawski et al., 2009 )

SpvC, HopA1 1 1 1 1

OspG Immunomodulation -

prevents I κ B degradation
and hence NF κ B activation

UbcH5, UbcH7 ( Kim
et al., 2005 )

NleH 1 1 1 1

Continued