Type 3 secretion effectors - Escherichia coli: Pathotypes and Principles of Pathogenesis - page 447

TABLE 15.2 T3SS effectors of Shigella

Number of T3SS effectors present in each
genome a

Interacting
proteins/ enzymatic
targets

Homolog (EPEC/
EHEC homologs in
bold)

S. dysenteriae
Sd197
300267

S. flexneri
Sf301
198214

S. boydii
Sb512
344609

S. sonnei
Ss046
300269

Effector Function

IpaA Invasion - induces actin

filament depolymerization

Vinculin ( Bourdet-
Sicard et al., 1999 )

SipA 1 1 1 1

IpaB Invasion - interacts with

NMEs to bring bacteria to
host cell membrane
Induces apoptosis through
IL-1 β release
Induces cell cycle arrest

MAD2B ( Iwai et al.,
2007 )
Caspase 1 ( Hilbi
et al., 1998 )

SipB, YopB 1 1 1 1

IpaC Invasion - recruits Src and

induces actin extensions
around bacteria

- SipC 1 1 1 1

IpaD Invasion - interacts with

NMEs to bring bacteria to
host cell membrane

- SipD 1 1 1 1

IpgB1 Rho GTPase modulation

- Rac1/Cdc42 GEF

Rac1, Cdc42 ( Huang
et al., 2009 ), ELMO
( Handa et al., 2007 )

EspM , SifA, SifB 1 1 1 1

IpgB2 Rho GTPase modulation

- RhoA GEF

RhoA ( Klink et al.,
2010 )

Map, EspT, SopE 1 1 1 1