Biology Reference
In-Depth Information
TABLE 15.1
T3SS effectors of A/E pathogens—cont'd
Effector
Function
Interacting proteins/
enzymatic targets
Homolog (
Shigella
homologs in bold)
EPEC1
E2348/69
O127:H6
EPEC2
B171
O11:NM
Atypical
EPEC E110019
O11:H9
Map
Rho GTPase
modulation - Cdc42
GEF
Induces apoptosis -
mitochondrial
disruption
TJ disruption
Ion channel disruption
Cdc42 (
Huang
et al., 2009
), EBP50
(NHERF1) (
Simpson
et al., 2006
),
NHERF2 (
Martinez
et al., 2010
)
IpgB2
1
1
1
NleA/
EspI
TJ disruption - disrupts
protein trafficking
Sec24 (
Kim et al.,
2007
), Syntrophin,
PDZK11, SNX27,
MALS3, TCOF1,
NHERF1/2, MAGI-3,
SAP97, SAP102,
PSD-95 (
Lee et al.,
2008
)
-
1
1
1
NleB
Immunomodulation -
inhibits TNF
α
induced
NF
κ
B activation
-
SARI_03503,
LTSEUGA_5597,
2(1)
1(2)
1
NleC
Immunomodulation -
cleaves p65, p50,
c-Rel, I
κ
B inhibiting
NF
κ
B activation
p65 (
Baruch et al.,
2011
), p50, c-Rel
(
Pearson et al.,
2011
), I
κ
B (
Michail
et al., 2003
), p300
(
Shames et al., 2011
)
Aip56
1
0(2)
0
NleD
Immunomodulation -
cleaves JNK and p38
to block AP-1 activation
JNK, p38 (
Baruch
et al., 2011
)
SARI_02033,
APM_0230,
1
0
0
NleE
Immunomodulation -
methylates and
inactivates TAB2 and 3
ubiquitin chain binding
activity to disrupt NF
κ
B
signaling
TAB2,3 (
Zhang et al.,
2012
)
OspZ
2
1
0
NleF
Unknown
-
PROVALCAL_00660,
SDY_P223
1
1
1
NleG
d
E3 ubiquitin ligase,
unknown cellular
function
UBE2D2 E2 ligase
(
Wu et al., 2010
)
STY1076
1
5
0
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