Type 3 secretion effectors - Escherichia coli: Pathotypes and Principles of Pathogenesis - page 441

TABLE 15.1 T3SS effectors of A/E pathogens—cont'd

Effector Function Interacting proteins/

enzymatic targets

Homolog ( Shigella
homologs in bold)

EPEC1
E2348/69
O127:H6

EPEC2
B171
O11:NM

Atypical
EPEC E110019
O11:H9

EspJ Inhibition of

phagocytosis (FC γ R-
and CR3-mediated)

- SboC, HopF2 1 0 0

EspK Unknown - GogB 0 0 1

EspL Intimate adhesion and

pedestal formation -
increases F-actin
bundling

Annexin 2 ( Miyahara
et al., 2009 )

OspD 1(2) 1(2) 1

EspM Rho GTPase

modulation - RhoA
GEF

RhoA ( Arbeloa et al.,
2008 )

IpgB1 , SopE 0 2 (1) 1

EspN Unknown - SARI_01330&01464,

SEHO0A_00314&01608,
CNF

0 1 0

EspO Cell integrity -

maintains focal
adhesions

Integrin-linked
kinase ( Kim et al.,
2009 )

OspE 0(1) 0 1(1)

EspR Unknown - - 0 1 1

EspS Unknown - OspB 0 1(1) 1

EspT Rho GTPase

modulation - Cdc42/
Rac1 GEF
Immunomodulation-
induces NF- κ B, Erk1/2
and JNK pathways
through Rac1

Cdc42, Rac1 ( Bulgin
et al., 2009 )

IpgB , SopE 0 0 1

EspV Actin remodeling -

unknown mechanism

- AvrA1, AvrBS1 0 0(1) 1 (1)

EspW Unknown - HopPmaA 0 1 1

EspX Unknown - SopA 0 0 0

EspY c Unknown - SopD 0 0 0

EspZ Inhibits cell cytotoxicity -

maintains focal
adhesions, reduces
loss of mitochondrial
membrane potential

CD98 ( Shames
et al., 2010 ), TIM17b
( Shames et al., 2011 )

- 1 1 1