Biology Reference
In-Depth Information
TABLE 15.1
T3SS effectors of A/E pathogens
Effector
Function
Interacting proteins/
enzymatic targets
Homolog (
Shigella
homologs in bold)
EPEC1
E2348/69
O127:H6
EPEC2
B171
O11:NM
Atypical
EPEC E110019
O11:H9
Cif
Rho GTPase
modulation - prevents
degradation of RhoA
Induces cell cycle arrest
through accumulation
of p21 and p27
NEDD8, Ub (
Cui
et al., 2010
)
YPK_1971,
Cifbp
0(1)
b
1
0
EspB
Inhibition of
phagocytosis
Microvilli effacement
Myosin 1c (
Iizumi
et al., 2007
),
α
-catenin (
Kodama
et al., 2002
),
α
1
-antitrypsin
(
Knappstein et al.,
2004
)
IpaC
, YopD
1
1
1
EspF
Induces apoptosis
Inhibition of
phagocytosis
TJ disruption
Ion channel disruption
Cytoskeletal integrity -
intermediate filaments
ABCF2 (
Nougayrede
et al., 2007
), SNX9
(
Marches et al.,
2006
), CK18, 14-3-
3zeta
Viswanathan
et al., 2004
), ZO-1,
ZO-2, Actin, Arp2/3,
N-WASP, Profilin
(
Peralta-Ramirez
et al., 2008
)
TccP2/EspF
U
1
1
1
EspG
Cytoskeletal integrity -
MT Disrupts cellular
trafficking Ion channel
disruption
Tubulin (
Matsuzawa
et al., 2004
), Rab
GTPases (Dong
et al 2012) ARF 1/6,
PAK1/2/3 (
Selyunin
et al., 2011
),
GM130, RACK1
(
Clements et al., 2011
)
VirA
2
1
1
EspH
Rho GTPase
modulation -
inactivation of DH-PH
Rho GEFs
Inhibition of
phagocytosis (FC
γ
R-
mediated)
Intimate adhesion and
pedestal formation
DH-PH Rho GEFs
(
Dong et al., 2010
)
-
1
1
1
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