Biology Reference
In-Depth Information
TABLE 9.1
Evidence that virulence factors contribute to colonization
and pathogenesis of urinary tract infection—cont'd
Attenuated
Mutant
2
Factor
Epidemiology
1
Complementation
3
Volunteers
4
Hma
✓
✓
IutA
✓
✓
IroN
✓
✓
FyuA
✓
Iha
✓
✓
IreA
✓
TraT
✓
CdtB
✓
IbeA
✓
OmpT
✓
K1 kpsM
✓
kpsM II
✓
RfaH
✓
TcpC
DraD/AfaD
Flagella
DegS
✓
✓
DegP
✓
✓
PhoU
✓
✓
PhoP
✓
✓
SisA and SisB
✓
(SisA only)
✓
✓
1
Gene or expression more frequent in UPEC than control strains.
2
Mutant in gene less able to cause UTI in animal model.
3
Ability to cause UTI restored to mutant by re-introduction of gene.
4
Evidence of role in UTI from experiments in humans.
5
Attenuation and complementation confirmed in murine model of chronic pyelonephritis.
6
Attenuated mutant also was hemolysin and serum resistance negative.
7
Did not reduce colonization in mouse model, however, there was significantly less damage
observed by histology.
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