Biology Reference
In-Depth Information
(a)
(b)
FIGURE 8.4
Scanning electron photomicrographs of
Macaca fascicularis
colon infected with EAEC
strain 042 for 3 hours (a) showing biofilm formation and mucosal intestinal toxicity which results in
dilation of crypt openings, rounding and exfoliation of colonic enterocytes, widening of intercrypt crev-
ices and loss of apical mucus from goblet cells
.
(b) Uninfected. Bar 50 µm. Photograph by Nadia Boisen.
that the
pic/set
genes are expressed in the intestinal lumen, and further results
suggest a novel mechanism of ShET1 regulation and the existence of pathogen-
specific regulators of
pic
and
setAB
. Pic is a 109-kDa mucinase, which degrades
intestinal mucin and may promote intestinal colonization via an unknown
mechanism (
Henderson et al., 1999a
).
Harrington et al., (2009)
showed that the
Search WWH ::
Custom Search