Shigella and enteroinvasive Escherichia coli: Paradigms for pathogen evolution and host–parasite interactions - Escherichia coli: Pathotypes and Principles of Pathogenesis - page 229

Thus, Shigella and EIEC have served as models of several aspects of pathogen
biology and provided paradigms that have been applied to other disease caus-
ing bacteria. Yet despite the advances in our knowledge of Shigella and EIEC
pathogenesis, there remain many mysteries at the genetic and cell biology lev-
els. Furthermore, in the absence of an effective vaccine against dysentery, these
pathogens will continue to be a formidable global threat to public health.
ACKNOWLEDGMENTS
Thanks to Kym Bliven, Sabrina Joseph, Miranda Gray and Manon Rosselin for their insightful
comments. Special thanks to Kym Bliven for drawing Figure 7.1 . Research on the genetics
of Shigella virulence in the Maurelli laboratory is supported by Public Health Service grant
AI24656 from the National Institute of Allergy and Infectious Diseases. The opinions or asser-
tions contained herein are the private ones of the author and are not to be construed as official
or as reflecting the views of the Department of Defense or the Uniformed Services University.
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