Biology Reference
In-Depth Information
TABLE 7.1
Shigella
virulence-associated loci encoded on the virulence
plasmid
Locus
Protein/activity
Role in virulence
Secreted effectors
ipaA
Vinculin activation
Invasion; binds vinculin; promotes F-actin
depolymerization
ipaB
Translocon pore
Invasion; lyses vacuole; controls T3S
secretion; anti-secretion plug
ipaC
Binds
β
-catenin
Invasion; induces cytoskeletal
reorganization; forms membrane pores
with IpaB
ipaD
Needle tip
Forms plug to modulate secretion
ipgB1
RhoG mimic
Activates Rac1; stimulates membrane ruffling
through the ELMO-Dock180 pathway
ipgB2
RhoA mimic
Triggers formation of actin stress fibers
ipgD
Phosphatidylinositol
4-phosphatase
Induces membrane blebbing and ruffling at
entry site in the host cell
icsA
Autotransporter
Catalyzes actin polymerization and intra-,
intercellular spread
virA
Activates calpain
Degrades p53 and inhibits p53/NF-
κ
B pathway
ipaH7.8
Escape from vacuole
ipaH9.8
E3 ubiquitin ligase
Downregulates host inflammatory response
ospB
Downregulates host inflammatory response
ospC1
Downregulates host inflammatory response
ospG
Protein kinase
Downregulates host inflammatory response
ospF
Phosphothreonine
lyase
Downregulates host inflammatory response
ospI
Glutamine
deamidase
Downregulates host inflammatory response
ospZ
Methyltransferase
Downregulates host inflammatory response
ospD3/senA
Enterotoxin
Induces fluid secretion
ospE
Stabilizes focal adhesins and prevents
detachment of infected cells
Chaperones
Partners
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