Biology Reference
In-Depth Information
TABLE 5.3
Effector proteins—cont'd
Effectors
Function or activity
TccP2
EspF
U
/TccP homolog (
Ogura et al., 2007
;
Ooka et al., 2007
;
Whale
et al., 2007
).
EspJ
Anti-opsonophagocytic (
Dahan et al., 2005
;
Marches et al., 2008
).
EspK
Colonization factor (Calves) (
Vlisidou et al., 2006
).
EspL2
Interacts with Annexin A2, induces microcolony formation and F-actin
aggregation (
Miyahara et al., 2009
;
Tobe, 2010
).
EspM1/M2
WxxxE family RhoA GEF (
Arbeloa et al., 2009
,
2010
); induces
stress fibers, modulates pedestal formation (
Arbeloa et al., 2008
);
alters polarized epithelial architecture (
Simovitch et al., 2010
).
EspI (NleA)
Colonization factor (
Lee et al., 2008
); binds Sec24 and inhibits COPII-
dependent vesicular transport (
Kim et al., 2007
;
Thanabalasuriar et al.,
2012
); disrupts tight junctions (
Thanabalasuriar et al., 2010a
,
b
); binds
PDZ domains (
Lee et al., 2008
).
NleB
Colonization factor (Cattle) (
Misyurina et al., 2010
); blocks nuclear
translocation of NF-
κ
B p65 subunit (
Nadler et al., 2010
;
Newton et al.,
2010
).
NleC
Zinc-metalloprotease that represses IL-8 secretion by cleaving NF-kB
and acetyltransferase p300 (
Yen et al., 2010
;
Baruch et al., 2011
;
Muhlen et al., 2011
;
Pearson et al., 2011
;
Sham et al., 2011
;
Shames
et al., 2011
).
NleD
Zinc-metalloprotease that inactivates JNK and diminishes IL-8
secretion (
Baruch et al., 2011
).
NleE
Inhibits NF-kB activation by blocking IkB degradation (
Nadler et al.,
2010
;
Newton et al., 2010
;
Vossenkamper et al., 2010
).
NleF
NleG/NleI
Colonization factor (Gnotobiotic piglets) (
Echtenkamp et al., 2008
)
U-Box-E3 ubiquitin ligase (
Li et al., 2006
;
Wu et al., 2010
).
NleH1/H2
Colonization factor (
Royan et al., 2010
); binds human ribosomal
protein S3 (RPS3), a cofactor of NF-kB transcriptional complex and
disrupts innate immune response (
Hemrajani et al., 2008
;
Gao et al.,
2009
;
Pham et al., 2012
); interacts with Bax inhibitor-1 to block
apoptosis (
Hemrajani et al., 2010
); decreases IKK-
β
-activity (
Royan
et al., 2010
).
NleL
E3 ubiquitin ligase; modulates pedestal formation (
Lin et al., 2011
;
Piscatelli et al., 2011
).
Cif
Cycle inhibiting factor; binds NEDD8 and blocks CRL ubiquitin ligase
activity (
Morikawa et al., 2010
); induces cell cycle arrest (
Marches
et al., 2003
;
Taieb et al., 2006
;
Cui et al., 2010
); induces delayed
apoptosis (
Samba-Louaka et al., 2009
).
Search WWH ::
Custom Search