Chemistry Reference
In-Depth Information
2. Nucleophiles often participate in nucleophilic substitution reactions. The general form
of these reactions may be represented by the following equation where Nu
1
2
and Nu
2
2
are nucleophiles:
a. Explain what type of relationship between Nu
1
2
and Nu
2
2
is necessary in order for
this reaction to be favored.
b. What does this say about the relative basicities of Nu
1
2
and Nu
2
2
?
c. Which nucleophile has the larger pK
a
?
d. What generalization can be concluded about the relationship between bases and
nucleophiles?
