Chemistry Reference
In-Depth Information
electrophilicity of the carbonyl carbon. The mechanism is illustrated below using
arrow pushing.
5. Explain the following products resulting from the reaction of amines with carbonyls.
Use arrow pushing and specify mechanistic types.
This is an addition-elimination reaction involving addition of methylamine to the
acid chloride and elimination of hydrochloric acid. The mechanism is illustrated
below using arrow pushing.
.
The product of this reaction is an imine resulting from 1,2-addition of methylamine
to the carbonyl followed by dehydration. Please note that in the dehydration step,
the amine contributes a hydrogen to match the leaving hydroxide group. The
mechanism is illustrated below using arrow pushing.
.
