Chemistry Reference
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Scheme 8.12 Friedel -Crafts acylation
While mechanistically distinct, the aldol condensation and the Friedel-Crafts acylation
result in the incorporation of additional carbon atoms to the starting structure. This type of
extension is extremely important when planning the synthesis of more complex organic
molecules. To this end, the greater the number of available reactions, the greater the
versatility in synthetic planning.
Thus far, the aldol condensation was presented as a method for adding carbon atoms
adjacent to carbonyl groups, and the Friedel -Crafts acylation was presented as useful for
the addition of carbon atoms to aromatic rings. In addition to these reactions, the
Wittig reaction (Scheme 8.13) and the Horner-Emmons reaction (Scheme 8.14) were
Scheme 8.13 Wittig reaction.
Scheme 8.14 Horner-Emmons reaction.
