Biomedical Engineering Reference
In-Depth Information
To this aim a more realistic modeling of the AV calcifications is also needed, since in
this study ideal and simplifiedmodels of AV stenosis were realized: this limitation can
be difficult to tackle due to the lack in the literature of morphological and mechanical
characterization of calcific AV leaflets.
Finally, a validation of the described FE models is needed to assess the reliability
of the results: at this aim, a comparison with an experimental bench test equipped
with a high-frequency acquisition camera in terms of macroscopic quantities should
be done.
In conclusion, a complete FE approach has been presented that allow the sim-
ulation of the different phases of TAV implantation and its function immediately
following the procedure. The possibility to investigate the biomechanics and the
dynamic behaviour of TAV has been demonstrated. The developed FEMs could be
applied to more realistic scenarios to support and direct clinical decisions.
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