Biomedical Engineering Reference
In-Depth Information
avoided; instead preformed structures are recommended. Several new shapes were
developed and simulated. For a few of them, significant stress reductions were ob-
served as compared with the initial scaffold. The improvement of the most promising
is to be confirmed through in vitro tests. With help of finite element simulations,
stresses and strains within scaffolds are predictable; therefore, different shapes can
be compared. With this, it is possible to narrow prospective options before costly test
series are performed. Consequently, developing time and expenses are reduced.
We also discussed the idea that newly developed scaffolds could possibly be
stressed too much due to heart movement. Therefore, it is recommended to enhance
the simulation and to validate it with in vitro tests. If stresses within the scaffolds are
still too high, another scaffold concept is recommended, see Fig.
9
. With this linked
scaffold, the handling effort is increased during surgery, but this is acceptable for an
implant that fulfills its function and exhibits low fatigue.
Acknowledgments
The authors are thankful to the German Research Foundation (DFG) for their
financial support. This project is funded within the Collaborative Research Center 599 (SFB 599)
and the International Research Training Group 1627 (GRK 1627). Furthermore, we thank Martina
Baldrich who developed scaffold shape 7 and Julian Schrader who developed shapes 8-12 in student
projects, respectively.
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