Biology Reference
In-Depth Information
19.3 Conclusions
We have written this chapter in the hope to raise the interest of cell biologist
readers toward these curious parasites. It is our belief that the study of these
organisms can result in many surprising discoveries as they go about their intra-
cellular life in such different ways. Often considered to be close relatives of each
other, as they belong to the apicomplexa phylum, already a superficial look at how
they divide shows the tremendous variation of solutions they present during their
distinct evolutionary paths. While they clearly share some of the key proteins with
other eukaryotes they also have distinct subsets of proteins at their disposal to
optimize cellular processes such as cell invasion and proliferation. Uncovering
these will contribute not just to the understanding of their parasitic way of life but
also to comprehend the basic principles of life itself.
Acknowledgments We thank Mirko Singer for reading the manuscript, Laboratório de Ul-
traestrutura Hertha Meyer (UFRJ-Brazil) for the access to their image archive and the Chica and
Heinz Schaller Foundation, the Cluster of Excellence CellNetworks at the University of Hei-
delberg and the German Research Foundation (SPP1399) for funding. FF is a member of the
European Network of Excellence EVIMalaR.
References
Agop-Nersesian C, Naissant B, Ben Rached F, Rauch M, Kretzschmar A, Thiberge S, Menard R,
Ferguson DJ, Meissner M, Langsley G (2009) Rab11A-controlled assembly of the inner membrane
complex is required for completion of apicomplexan cytokinesis. PLoS Pathog 5:e1000270
Agop-Nersesian C, Egarter S, Langsley G, Foth BJ, Ferguson DJ, Meissner M (2010) Biogenesis
of the inner membrane complex is dependent on vesicular transport by the alveolate specific
GTPase Rab11B. PLoS Pathog 6:e1001029
Aikawa M, Beaudoin RL (1968) Studies on nuclear division of a malarial parasite under
pyrimethamine treatment. J Cell Biol 39:749-754
Amino R, Thiberge S, Martin B, Celli S, Shorte S, Frischknecht F, Menard R (2006) Quantitative
imaging of Plasmodium transmission from mosquito to mammal. Nat Med 12:220-224
Arnot DE, Ronander E, Bengtsson DC (2011) The progression of the intra-erythrocytic cell cycle
of Plasmodium falciparum and the role of the centriolar plaques in asynchronous mitotic
division during schizogony. Int J Parasitol 41:71-80
Azimzadeh J, Marshall WF (2010) Building the centriole. Curr Biol 20:R816-R825
Bannister LH, Hopkins JM, Fowler RE, Krishna S, Mitchell GH (2000) A brief illustrated guide to
the ultrastructure of Plasmodium falciparum asexual blood stages. Parasitol Today 16:427-433
Barr FA, Gruneberg U (2007) Citokinesis: placing and making the final cut. Cell 131:847-860
Baum J, Gilberger TW, Frischknecht F, Meissner M (2008) Host-cell invasion by malaria
parasites: insights from Plasmodium and Toxoplasma. Trends Parasitol 24:557-563
Baumgartner M (2011) Enforcing host cell polarity: an apicomplexan parasite strategy towards
dissemination. Curr Opin Microbiol 14:436-444
Borrmann S, Matuschewski K (2011) Protective immunity against malaria by 'natural immuni-
zation': a question of dose, parasite diversity, or both? Curr Opin Immunol 23:500-508
Brooks CF, Francia ME, Gissot M, Croken MM, Kim K, Striepen B (2011) Toxoplasma gondii
sequesters centromeres to a specific nuclear region throughout the cell cycle. Proc Nat Acad
Sci USA 108:3767-3772
Search WWH ::




Custom Search