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our previous findings that centrosome amplification correlated with high-risk
genetic aberrations, such as chromosome 13 deletion, t(4; 14), and t(14; 16),
further studies are needed to understand if centrosome abnormalities contribute to
the formation of structural chromosomal abnormalities.
Given the existing evidence which suggests an important role for centrosome
abnormalities in oncogenesis in general, we envisage that a deeper understanding
of centrosome biology in MM will, in time, reveal novel candidates and strategies
for therapy, and subsequently translate into enhanced patient care.
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