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(Bartkova et al.
2005
; Gorgoulis et al.
2005
). This activation of the DNA damage
response constrains tumourigenesis by inducing cell cycle delay, cell death or senes-
cence, so that cells that no longer respond normally to DNA damage signals have a
selective advantage in tumour development (Bartkova et al.
2005
,
2006
; Braig et al.
2005
; Gorgoulis et al.
2005
). However, the potential contribution of centrosome
amplification to aneuploidy might make it a rather hazardous component of the normal
DNA damage response or mechanism of cell death. Nevertheless, it is interesting to
speculate that inducing centrosome amplification might be a means by which the
killing effects of DNA damaging treatments could be potentiated.
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