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in the future studies. As described in this chapter, the key cell cycle-associated
events, including centrosome duplication, are linked by the common regulatory
proteins and pathways, and that many of those regulatory proteins are oncogenic and
tumor suppressor proteins frequently mutated in cancers (Fukasawa
2007
). Muta-
tional activation or inactivation of those regulatory proteins can lead to uncoupling of
centrosome duplication from other cell cycle-associated events, which lays a ground
for occurrence of centrosome amplification, and consequentially destabilization of
chromosomes, and thus profoundly influences the tumor development.
Acknowledgments The preparation of this manuscript is in part supported by the grants from
National Institute of Medicine and State of Florida.
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