Biology Reference
In-Depth Information
cycling irrespective of the p53 status (i.e., imbalance or deprivation of critical
molecules such as dNTPs similar to the situation experimentally induced by HU
treatment). In such cases, centrosomes reduplicate if cells lack functional p53,
leading
to
centrosome
amplification.
Once
the
stress-causing
problems
are
resolved, those cells resume cell cycling with amplified centrosomes.
