Biology Reference
In-Depth Information
Table 1.1
Drosophila genes involved in centrosome biogenesis
Name
CG ID
Ortholog
Localization
in Drosophila
Phenotype
Additional information
References
Asl
CG2919
Cep152
(MCPH4)
Centriole PCM
interphase
Uncoordinated
Meiosis defect
Nonmotile sperm
Complete block of centriole
and centrosome
formation in mutant
(Blachon et al.
2008
;
Bonaccorsi et al.
1998
;
Varmark et al.
2007
)
Ana1
CG6631
KIAA1731
Centrosome
Uncoordinated
Meiosis defect
Nonmotile sperm
Essential for centrosome
formation
(Blachon et al.
2009
;
Goshima et al.
2007
)
Ana2
CG8262
STIL
Centrosome
Unknown
Induces cartwheel-like
structures together with
Sas-6
(Goshima et al.
2007
;
Stevens et al.
2010a
)
Ana3
CG13162
Rttn
Centrosome
Uncoordinated
Required for centriole
structural integrity
(Goshima et al.
2007
;
Stevens et al.
2009
)
Sak
CG7186
Plk4
Centrosome
Uncoordinated
Meiosis defect
Nonmotile sperm
Essential for centrosome
formation
(Bettencourt-Dias et al.
2005
)
Sas-4
CG10061
CPAP
(MCPH6)
TCP10
Centriole and PCM
Uncoordinated
Meiosis defect
Nonmotile sperm
Essential for centrosome
formation
Short mc-giant centriole in
mutants
(Basto et al.
2006
; Blachon
et al.
2009
;
Gopalakrishnan et al. in
press)
Sas-6
CG15524
Sas-6
Cartwheel
Uncoordinated
Meiosis defect
Nonmotile sperm
Centrioles that lack
symmetry in mutant;
Central tubule protein
(Gopalakrishnan et al.
2010
; Rodrigues-
Martins et al.
2007a
;
Stevens et al.
2010b
)
D-Plp
CG6735
Pericentrin
AKAP450
Centrosome
Uncoordinated
Nonmotile sperm
Essential for PCM
formation
(Martinez-Campos et al.
2004
)
Cnn
CG4832
CDK5RAP2
(MCPH3)
Myomegalin
Centrosome, PCM
Meiosis defect
Nonmotile sperm
Essential for PCM
formation
(Heuer et al.
1995
; Li et al.
1998
; Megraw et al.
1999
; Vaizel-Ohayon
and Schejter
1999
)
(continued)
