Biology Reference
In-Depth Information
and whether this core centriole assembly factor is regulated by degradation across
species is an open question. Given that phosphorylation is often the trigger for SCF-
dependent degradation, it is tempting to speculate that PP2A removes a phosphate to
antagonize SCF-dependent degradation. However, it has not yet been demonstrated
that Sas-5 is degraded, and PP2A can also promote SCF-dependent degradation as it
does for c-myc (Sears 2004 ). The role of PP2A in the control Sas-5 therefore can't be
predicted, and it will be exciting to watch the story of regulated Sas-5 degradation
develop. Moreover, at least three factors that can cause centriole overproduction in
human cells, Mps1, Plk4, and hSas6, are regulated by degradation. Whether proteins
such as Ana2 and Asterless that can cause centrosome re-duplication in flies (Ste-
vens et al. 2010 ) are also controlled by regulated degradation is also not yet known.
Given how critical it is for centrosome duplication to occur just once each cell cycle,
it seems likely that regulated degradation will ultimately be shown to be a common
feature of centriole assembly factors.
References
Adams IR, Kilmartin JV (2000) Spindle pole body duplication: a model for centrosome
duplication? Trends Cell Biol 10:329-335
Amsterdam A, Pitzer F, Baumeister W (1993) Changes in intracellular localization of
proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role
in cell cycle control. Proc Natl Acad Sci U S A 90:99-103
Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (2003) Proteomic
characterization of the human centrosome by protein correlation profiling. Nature 426:570-574
Anton LC, Schubert U, Bacik I, Princiotta MF, Wearsch PA, Gibbs J, Day PM, Realini C,
Rechsteiner MC, Bennink JR, Yewdell JW (1999) Intracellular localization of proteasomal
degradation of a viral antigen. J Cell Biol 146:113-124
Arrigo AP, Tanaka K, Goldberg AL, Welch WJ (1988) Identity of the 19S 'prosome' particle
with the large multifunctional protease complex of mammalian cells (the proteasome). Nature
331:192-194
Azimzadeh J, Marshall WF (2010) Building the centriole. Curr Biol 20:R816-825
Azimzadeh J, Hergert P, Delouvee A, Euteneuer U, Formstecher E, Khodjakov A, Bornens M
(2009) hPOC5 is a centrin-binding protein required for assembly of full-length centrioles.
J Cell Biol 185:101-114
Baugh JM, Viktorova EG, Pilipenko EV (2009) Proteasomes can degrade a significant proportion
of cellular proteins independent of ubiquitination. J Mol Biol 386:814-827
Beauchene NA, Diaz-Martinez LA, Furniss K, Hsu WS, Tsai HJ, Chamberlain C, Esponda P,
Gimenez-Abian JF, Clarke DJ (2010) Rad21 is required for centrosome integrity in human
cells independently of its role in chromosome cohesion. Cell Cycle 9:1774-1780
Bembenek J, Yu H (2001) Regulation of the anaphase-promoting complex by the dual specificity
phosphatase human Cdc14a. J Biol Chem 276:48237-48242
Biggins S, Ivanovska I, Rose MD (1996) Yeast ubiquitin-like genes are involved in duplication of
the microtubule organizing center. J Cell Biol 133:1331-1346
Brooks L 3rd, Heimsath EG Jr, Loring GL, Brenner C (2008) FHA-RING ubiquitin ligases in cell
division cycle control. Cell Mol Life Sci 65:3458-3466
Brown CR, Doxsey SJ, White E, Welch WJ (1994) Both viral (adenovirus E1B) and cellular (hsp
70, p53) components interact with centrosomes. J Cell Physiol 160:47-60
Search WWH ::




Custom Search