Biology Reference
In-Depth Information
Table 7.1 Factors that control the positioning of the Golgi ribbon next to the centrosome
Protein class
Examples
Role in Golgi
positioning
Golgi phenotype
(when activity of the
regulatory factor is altered)
References
Microtubules and associated proteins
Centrosome-nucleated microtubules
Radial array with plus
ends extending in all
directions toward the
cell periphery
Critical for C-stage of
Golgi reassembly
Dispersed Golgi mini-stacks
Cole et al. (
1996
)
Golgi-nucleated microtubules
Asymmetric array with
plus ends extending
toward the leading
edge of the cell
Critical for G-stage of
Golgi reassembly
Golgi membrane clusters in
periphery, no ribbon
Efimov et al. (
2007
), Miller et al. (
2009
)
Dynein
Responsible for
directional
movement of Golgi
toward the
centrosome (toward
the minus ends of
microtubules)
Dispersed Golgi mini-stacks
Corthesy-Theulaz et al. (
1992
),
Harada et al. (
1998
)
Kinesin
Providing opposing
force to dynein
activity
Encourages lateral
spreading of Golgi
membranes
Minus-end directed
kinesin activity has
similar role as dynein
Collapsed Golgi in cell
center
Dispersed Golgi mini-stacks
Feiguin et al. (
1994
)
Xu et al. (
2002
)
(continued)
