Human Centrosomal Dynamics During Gametogenesis, Fertilization, and Embryogenesis and Its Impact on Fertility: Ultrastructural Analysis - The Centrosome - page 89

Fig. 5.24 Abnormal centrioles in sperm of infertile men with OATS. The functional centriole is
absent or abnormal in the'black box'. Note peculiar material in adjacent cytoplasmic droplet
x 85,000 (Sathananthan 1996 )
Fig. 5.25 Centrosome: molecular dissection. The sperm centrosome is unravelled, expanded,
and everted in the zygote. The binding of Ca ++ ions to centrin during activation is thought to
release the sperm centrosome (Courtesy Schatten 1994 )
5.11 Sperm Centrosomes and Infertility
In 1991, we postulated a hypothesis that if a defective male centrosome is inherited
by a human oocyte, it might lead to abnormal cleavage and compromise embry-
onic development, a new dimension in the assessment of infertility (Sathananthan