Biology Reference
In-Depth Information
Pertinent to this is that the two ligand binding sites of ABA-1 are different
and have characteristics that may mean that they carry different classes of
compound with potentially different biological activities
93
. Ascaris may
yet have much to teach us about how nematodes modulate the immune
system of their hosts. Why, for instance, do Ascaris larvae undergo a pro-
longed, hazardous, and seemingly unnecessary tissue migration from the
intestine back to the intestine? Is it merely because their ancestors had
intermediate hosts and their lineage cannot escape from having
a compulsory migratory stage? Or is it in order to modify the immune
response in their favor for when they settle down to reproduce, or to
prepare the way for their successor larvae?
Acknowledgments
Most if not all of the research reported here was supported by the Wellcome Trust, UK.
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