Biology Reference
In-Depth Information
TABLE 16.3 Overview of the vaccination experiments performed against A. suumdcont'd
Year
Antigen
Immunization protocol
Host
Recovered stage
% Reduction
Reference
2001
As14 recombinant
3 i.n. immunizations with
rAs14 coupled to CT-B
Mice
Lung larvae
64%
g
2002
As37 recombinant
3 immunizations with rAs37 in FCA
Mice
Lung larvae
N.S.
h
2001
14kDa PF fraction
42kDa PF fraction
97kDa BW fraction
6 s.c. immunizations of antigen in FIA
Pigs
Lung larvae
88%
77%
50%
i
2003
As16 recombinant
3 i.n. immunizations with
rAs16 coupled to CT-B
Mice
Lung larvae
58%
j
2004
As16 recombinant
3 i.n. immunizations with
rAs16 coupled to CT-B
Pigs
Lung larvae
58%
k
2005
As24 recombinant
3 s.c. immunizations with rAs24 in FCA
Mice
Lung larvae
58%
l
2008
As16 recombinant
As16 fused to CT-B expressed
in rice and fed to mice
Mice
Lung larvae
Not mentioned
but significant
79
2011
A. suum hemoglobin
(AsHb)
3 i.m. immunizations with AsHb
þ
Pigs
L4, L5 and
adults
N.S.
36
QuilA
2012
Recombinant A. suum
enolase
3 i.m. immunizations with pVAX-Enol
DNA
Mice
Lung larvae
61%
m
PF= pseudocoelomic fluid, BW = adult body wall. UV-eggs
¼
eggs attenuated by UV-radiation; N.S.
¼
not significant; s.c.
¼
subcutaneous; i.m.
¼
intramuscular; i.n.
¼
intranasal; w/wo
¼
with or without; CT-B
¼
Cholera Toxin subunit B; FCA
¼
Freund's Complete Adjuvant; FIA
¼
Freund's Incomplete Adjuvant, AsHb = A. suum
haemoglobin.
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