Decoding the Ascaris suum Genome using Massively Parallel Sequencing and Advanced Bioinformatic Methods e Unprecedented Prospects for Fundamental and Applied Research - Ascaris: The Neglected Parasite - page 289

TABLE 11.3 Summary of the Ascaris suum excretory/secretory
proteins, predicted to play a key role in immuno-
modulation, -regulation and/or -evasion in the
host animal

Predicted role Number of genes (%)

Immunogen 301 (78.4)

O-linked glycan 300

Omega-1 ribonuclease 1

Immunogen/inhibitor 17 (4.4)

SCP/TAPs (VAL) a

17

Inhibitor/immunomodulator 26 (6.8)

Aminopeptidase 2

Cystatin 2

Serpin 11

SmSP1 b

1

Galectin 8

Calreticulin 2

Mimicry 18 (4.7)

C-type lectin 7

Lectin 6

MIF c

2

TGF- b like 2

Oxidoreductase 14 (3.6)

Glutathione peroxidase 5

Peroxidase 1

Superoxide dismutase 3

Thioredoxin peroxidase 5

Anti-inflammatory 5 (1.3)

PAFA d

5

Others 3 (0.8)

ALT1,2 e

3
a SCP/TAPS (VAL), Sperm Coating Protein/Tpx-1/Ag5/PR-1/Sc7 (venom allergen-
like) proteins.
b SmSP1, serine protease inhibitor (serpin) 1 encode in Schistosoma mansoni
(human blood fluke).
c MIF, macrophage initiation factor 4 mimic.
d PAFA, platelet anti-inflammatory

.
e ALT1, 2, abundant larval transcripts 1 and 2, encoded in Brugia malayi .

a