Biology Reference
In-Depth Information
OUTLINE
Introduction
288
Advanced Methodologies Established to Sequence, Assemble, and
Annotate the Genome and Transcriptomes of
A. suum
290
Sequencing of the Genome from the DNA from the Reproductive Tract
from a Single Adult Female of A. suum
290
Genome Assembly
293
Gene Prediction and Annotation
293
Salient Characteristics of the Genome and Transcriptomes of
A. suum
: Toward Understanding the Molecular Landscape of the
Parasite and the Design of New Interventions
297
Characterizing the Genome
297
The Gene Set
298
Molecular Groups Involved in Key Biological Functions
300
Transporters and Channels
300
301
Key Classes of Enzymes
ES Peptides
302
Key Molecules Involved in Parasite
e
Host Interactions
e
Elucidating the Biology of A. Suum and Parasite
e
Host Interactions from
Transcriptomic Datasets
304
304
Reproduction and Development in the Adult Stage
305
Hepatopulmonary Migration of Larval Stages
Prediction and Prioritization of Drug Targets
305
Conclusions, Implications, and Major Prospects for Fundamental and
Applied Research
307
References
310
INTRODUCTION
Ascaris
is among the commonest and most important parasites of
humans globally, infecting
1.2 billion people and causing significant
nutritional deficiency, impaired physical and cognitive development, and,
in severe cases, death.
1
Ascariasis has the greatest impact in people of
5
w
e
15 years of age, particularly in impoverished populations in devel-
oping countries (see Chapter 13). This disease also has a substantial
impact on the growth and productivity of one of the world's major food
animals, pigs, resulting in reduced growth,
failure to thrive and
