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genomes and launch a more detailed transcriptomic exploration of Ascaris
in the two hosts which might reveal a more complicated set of heritable
factors and epigenetic traits that are required to maintain parasite trans-
mission across different definitive hosts. From this molecular perspective,
the key challenge is to scale up the relevance of such genetic and genomic
studies and quickly apply them to ongoing experimental studies and on-
the-ground control interventions.
Acknowledgments
We warmly thank Professor Celia Holland for inviting us to write this chapter and feature
our joint work on the biology of Ascaris. We also gratefully acknowledge the long list of
colleagues we have worked with in Africa and Europe who have generously given their time
to the study of neglected tropical diseases.
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