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FIGURE 10.2
sampled from humans living in
three Ugandan and four Zanzibari villages. Pie charts show relative proportions of
different haplotypes at each location. It is apparent that some locations have greater
diversity than others, despite a similar number of worms sampled.
Cox
1 haplotype diversity in
Ascaris
farmed pig production several decades ago, so greater attention on these
historical environmental heterogeneities would be well placed, 42 which
might reveal a much longer-term asynchronicity of worm populations. At
the very least, documenting present genetic information relating to Ascaris
on Zanzibar will become ever more important when set against future
molecular investigations and control goals, especially if an archive
collection of worms (preserved in ethanol) or genomic DNA is maintained
for future investigations as more advanced genetic profiling techniques
come online.
CONCLU DING REMARKS AND FUTURE STUDIES
It is heartening to see the growing interest in the molecular scrutiny of
Ascaris given its global importance as a longstanding disease across the
globe. A key question still remains
what is the present genomic
diversity of Ascaris across its endemic range and are there genomic islands
of variation which manifest themselves at the phenotypic level in terms of
host specificity, pathogenicity, and drug sensitivity? Since the genome and
transcriptome of A. suum is now available 97 e 99 (see Chapter 11) and that of
A. lumbricoides is on its way, an important step will be to compare the
e
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