Biology Reference
In-Depth Information
TABLE 7.2 Summary of chemo-expulsion studies that have collected adult Ascaris
lumbricoides from humans by study starting date
Age range
(years)
Study
type
Location
Study period
Participants
*
Drug
Reference
Iran
1972
e
1973
652
5
e
40
þ
PYR
CX
245
Iran
1973
e
1974
252
0
e
45
þ
PYR
CX
205
South Korea
1975
e
1978
853
NA
PYR
CX
246
South Korea
1977
e
1980
NA
NA
PYR
LG
247,248
Bangladesh
1982
203
0.5
e
15
PYR
CX
249
Burma
(Myanmar)
1982
239
5
e
39
þ
LEV
LG
112,58
Philippines
1983
308
primary
school
FLU
CX
250
Panama
1983
e
1984
203
3
e
5
LEV
CX
251
India
1984
e
1985
224
2
e
65
þ
PYR
LG
19
Philippines
1985
e
1986
150
0
e
14
PYR
CX
252
Mexico
1986
118
2
e
10
MBZ
LG
81
Nigeria
1987
808
5
e
16
LEV
LG
59
NA
y
e
þ
St. Lucia
113
1
30
MBZ
LG
158
Bangladesh
1988
e
1989
1,765
1
e
98
PYR
LG
98
Madagascar
1990
e
1992
428
5
e
11
PYR
LG
253
China
1994
e
1995
222
0
e
55
þ
PYR
CX
254
Nepal
1998
e
2003
1,007
3
e
85
ABZ
LG
77
* The number of participants whose worm burden was successfully assessed after anthelmintic treatment. For
longitudinal studies, this is the number after the first round of treatment.
y
Not reported in the published literature.
Drug abbreviations: ABZ, albendazole; FLY, flubendazole; LEV, levamisole; MBZ, mebendazole; PYR,
pyrantel.
Study type abbreviations: CX, cross-sectional; LG, longitudinal.
An extremely important research application of anthelmintics, partic-
ularly pyrantel pamoate, is their use as chemo-expulsive agents for
collecting adult worms (
Table 7.2
), the gold-standard data for estimation
of infection intensity. Pyrantel pamoate is particularly suitable for this
purpose since it paralyzes adult worms
e
rather than killing and poten-
tially damaging them
e
which are then expelled intact from the gut by
peristalsis.
