Biology Reference
In-Depth Information
CHAPTER
7
Ascaris lumbricoides: New
Epidemiological Insights and
Mat hematical Approa ches
Martin Walker * , Andrew Hall y ,
Marı ´ a-Gloria Bas ´ ˜ez *
* Imperial College London, London, UK
y University of Westminster, London, UK
OUTLINE
Introduction
156
Biology and Life-Cycle
157
Morbidity and Mortality due to Ascariasis
158
Treatment
158
Diagnosis of Infection
161
Transmission in Communities
163
Quantifying Infection
163
Heterogeneities in Infection
164
165
The Role of Host Genetics
165
The Role of Host Immunity
Reinfection following Curative Treatment
168
Mathematical Approaches
170
Statistical Models
171
Negative Binomial and Zero-inflated Negative Binomial
Distributions
171
Regression Models
173
Hierarchical, Mixed Effects Models
175
Spatial and Spatial
e
Temporal Models
176
 
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