Biology Reference
In-Depth Information
antigen fractions derived from Ascaris parasites with anti-inflammatory
effects could be developed as novel therapies for inflammatory diseases
but there is no indication for the use of natural infections in the treatment
of allergic or autoimmune diseases.
A better understanding of the host
parasite interaction in humans
and how this interaction affects immune modulation during ascariasis
and the clinical effects of such modulation will be provided by obser-
vational and intervention studies that are currently in progress and that
have followed and sampled cohorts of children living in endemic
communities from the time of pregnancy. In many regions of the world,
the prevalence of human ascariasis is progressively declining with
economic development and greater access to sanitation and clean water.
However, it could be argued that while the clinical effects of immune
modulation associated with chronic infections will inevitably diminish
in such populations, the inflammatory consequences of acute and
intermittent infections will grow considerably (e.g. asthma), particularly
among the urbanizing poor whose conditions of life are unlikely to
improve sufficiently to eliminate the infection but rather will ensure its
continued survival.
e
References
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