Serum and Plasma Collection: Preanalytical Variables and Standard Operating Procedures in Biomarker Research - Proteomic and Metabolomic Approaches to Biomarker Discovery - page 75

CHAPTER
5

Serum and Plasma Collection:
Preanalytical Variables and Standard
Operating Procedures in Biomarker
Research

Melissa Tuck 1 , D. Kim Turgeon 2 ,
Dean E. Brenner 3
1 Project Manager, Cancer Prevention Clinical Research, University of Michigan, Ann Arbor, MI, USA,
2 Clinical Associate Professor of Internal Medicine, University of Michigan, Ann Arbor, MI, USA,
3 Kutsche Family Professor of Internal Medicine, Professor of Pharmacology,
University of Michigan and VA Medical Center, Ann Arbor, MI, USA

OUTLINE

Introduction 78 Other Biosamples 83

Importance of Preanalytical Variables 78 Blood-Borne Pathogens, Universal

Precautions, and Safety 83

Standard Operating Procedures (SOP S ) 79

Human Subject Research Protections 83

Sample Selection Considerations 81

Conclusions 85

Human Blood and Its Components 81

Serum 82 References 85

Plasma 83

Hemolyzed Samples 83