Biology Reference
In-Depth Information
TABLE 4
Examples of Autoantibodies Identi
ed using Proteomic Technologies
Antigen Sources
Example antigens
Example diseases
References
cDNA expression
Phage plaque/display
SSX-2
PC326 and others
IFI16 and others
Five-phage peptide
Melanoma
Moyamoya disease
Sjogren
29
28
30
27
s syndrome
Colorectal carcinoma
'
Phage display & microarray
A panel of 22 peptides
Ubiquilin 1
Prostate cancer
Lung
33
35
Cell lysates
2D Western
Annexin I and II
mtHSP70
Lung cancer
Multiple sclerosis
36
37
Natural protein array
LAMR1
Lung cancer
38
Recombinant proteins
Puri
ed proteins
RALBP1 and others
Kelch-like protein 12 and others
RPS20 and others
Panel of antigens
A panel of 10 antigens
Ovarian cancer
Primary biliary cirrhosis
Autoimmune hepatitis
Rheumatoid arthritis
Alzheimer
40
39
43
41
,
44
42
'
s disease
In vitro expression mixtures
Various
Infectious disease
(Burkholderia pseudomallei)
50
On-chip synthesized proteins
A panel of 28 antigens
Panel of antigens
Breast cancer
ankylosing spondylitis
45
48
Synthetic peptides
Synthetic peptides/peptoids
on arrays
A panel of peptides
Several peptoids
Glycopeptides derived from
mucins
Alzheimer
s disease
56
58
55
'
Alzheimer
s disease
Colorectal cancer
'
Synthetic human peptidome &
phage display
Various
Paraneoplastic neurological
disorder
57
Microbial surface display
HSP60
Plasminogen binding protein
(PBP)
GRP78
Atherosclerosis
Autoimmune pancreatitis
Prostate cancer
53
51
52
Cancer
Cancer is the second most common cause of
death in the United States. In 2012, there will be
an estimated 1.6 million new cases of cancer and
over 500,000 deaths (
http://www.cancer.org
),
Although Alzheimer
is is not considered an
immune-mediated disorder, autoantibodies to
peptoid libraries have been speci
'
cally identi-
s patients, which
may be biomarkers for disease diagnosis.
58
fied in the sera of Alzheimer
'
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