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candidates for bladder cancer. However, these
results have not been validated. A 2D-DIGE
study was carried out for the identi
of Health, under Contract HHSN261200800001E. The
content of this publication does not necessarily re
ect the
views or policies of the Department of Health and Human
Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the United
States Government.
cation of
nuclear matrix proteins to investigate their diag-
nostic and prognostic roles in invasive bladder
cancer.
15
The study used 3 normal, 9 nontumor
tissue specimens, and 21muscle-invasive bladder
cancers. More than 800 protein spots were
detected, of which 30 proteins were differentially
expressed by bladder tumor cells. Banerjee et al.
16
used 2D-DIGE followed by spot picking and
analysis of proteins/peptides by MS to search
for protein biomarkers for brain cancer. They
report that they identi
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Acknowledgment
This project has been funded in whole or in part with federal
funds from the National Cancer Institute, National Institutes
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of differentially expressed protein by 2-D DIGE.
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