Production Techniques - Lipid Nanoparticles: Production, Characterization and Stability - page 39

3.3 Conclusions
Several production techniques are available and have been discussed in this chap-
ter. The particle characteristics of the lipid nanoparticles is expected to be greatly
influenced by the choice of method employed in its production (see next chapter).
The choice of method also depends on the composition of the lipid nanoparticle
formulation. Table 3.1 outlines the various techniques discussed here with the pos-
sible mechanism involved in particle formation. Each of the methods developed to
date have their own advantages and disadvantages (also discussed in Table 3.1 ).
A novel method developed by the authors is a rapid technique with many advan-
tages, and few disadvantages, but may face limitations in scalability and is not yet
fully tested. Based on literature, it can thus be concluded that no method is perfect,
and choice of method will depend on availability of equipment, composition of the
lipid formulation and desired property outcomes.
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