Biology Reference
In-Depth Information
121. McDaniel R, Kao CM, Fu H, et al. Gain-of-function mutagenesis of a modular polyketide synthase.
J Am Chem
Soc
. 1997;119:4309
4310.
122. Kao CM, McPherson M, McDaniel RN, Fu H, Cane DE, Khosla C. Gain of function mutagenesis of the
erythromycin polyketide synthase. 2. Engineered biosynthesis of eight-membered ring tetraketide lactone.
J Am Chem Soc
. 1997;119:11339
11340.
123. Oliynyk M, Brown MJB, Cortes J, Staunton J, Leadlay PF. A hybrid modular polyketide synthase obtained by
domain swapping.
Chem Biol
. 1996;3:833
839.
124. Liu L, Thamchaipenet A, Fu H, Betlach M, Ashley G. Biosynthesis of 2-nor-6-deoxyerythronolide B by
rationally designed domain substitution.
J Am Chem Soc
. 1997;119:10553
10554.
125. Ruan X, Pereda A, Stassi DL, et al. Acyltransferase domain substitutions in erythromycin polyketide synthase
yield novel erythromycin derivatives.
J Bacteriol
. 1997;179:6416
6425.
126. Kuhstoss S, Huber M, Turner JR, Paschal JW, Rao RN. Production of a novel polyketide through the
construction of a hybrid polyketide synthase.
Gene
. 1996;183:231
236.
127. Marsden AFA, Wilkinson B, Cortes J, Dunster NJ, Staunton J, Leadlay PF. Engineering broader specificity into
an antibiotic-producing polyketide synthase.
Science
. 1998;279:199
202.
128. Dutton CJ, Gibson SP, Goudie AC, et al. Novel avermectins produced by mutational biosynthesis.
J Antibiot
.
1991;44:357
365.
129. Cane DE, Yang CC. Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into
erythromycin.
J Am Chem Soc
. 1987;109:1255
1257.
130. Yue S, Duncan JS, Yamamoto Y, Hutchinson CR. Macrolide biosynthesis
tylactone formation involves the
processive addition of 3 carbon units.
J Am Chem Soc
. 1987;109:1253
1255.
131.
Jacobsen JR, Hutchinson CR, Cane DE, Khosla C. Precursor-directed biosynthesis of erythromycin analogs
by an engineered polyketide synthase.
Science
. 1997;277:367
369.
132. Chuck JA, McPherson M, Huang H, Jacobsen JR, Khosla C, Cane DE. Molecular recognition of diketide
substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase.
Chem Biol
. 1997;4:757
766.
133. McDaniel R, Kao CM, Hwang SJ, Khosla C. Engineered intermodular and intramodular polyketide synthase
fusions.
Chem Biol
. 1997;4:667
674.
134. Behrens OK, Corse J. Biosynthesis of penicillins; new crystalline biosynthetic penicillins.
J Biol Chem
.
1948;175:793
204
809.
135. Daum SJ, Lemke JR. Mutational biosynthesis of new antibiotics.
Annu Rev Microbiol
. 1979;33:241
265.
136. Khaw LE, Bohm GA, Metcalfe S, Staunton J, Leadlay PF. Mutational biosynthesis of novel rapamycins by a
strain of
Streptomyces hygroscopicus
NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.
J Bacteriol
. 1998;180:809
814.
137. Liu HW, Thorson JS. Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.
Annu Rev
Microbiol
. 1994;48:223
256.
138. Decker H, Haag S, Udvarnoki G, Rohr J. Novel genetically-engineered tetracenomycins.
Angew Chem Int Edit
Engl
. 1995;34:1107
1110.
139. Solenberg PJ, Matsushima P, Stack DR, Wilkie SC, Thompson RC, Baltz RH. Production of hybrid
glycopeptide antibiotics
in vitro
and in
Streptomyces toyocaensis
.
Chem Biol
. 1997;4:195
202.
140. Madduri K, Kennedy J, Rivola G, et al. Production of the antitumor drug epirubicin (4
0
-epidoxorubicin) and
its precursor by a genetically engineered strain of
Streptomyces peucetius
.
Nat Biotechnol
. 1998;16:69
74.
141. Stachelhaus T, Schneider A, Marahiel MA. Engineered biosynthesis of peptide antibiotics.
Biochem Pharmacol
.
1996;52:177
186.
142. Donadio S, Monciardini P, Sosio M. Polyketide synthases and nonribosomal peptide synthetases: the
emerging view from bacterial genomics.
Nat Prod Rep
. 2007;24:1073
1109.
143. Bentley SD, Chater KF, Cerdeno-Tarraga AM, et al. Complete genome sequence of the model actinomycete
Streptomyces coelicolor
A3(2).
Nature
. 2002;417:141
147.
144. Challis GL. Genome mining for novel natural product discovery.
J Med Chem
. 2008;51:2618
2628.
145. Bergmann S, Schumann J, Scherlach K, Lange C, Brakhage AA, Hertweck C. Genomics-driven discovery of
PKS-NRPS hybrid metabolites from
Aspergillus nidulans
.
Nat Chem Biol
. 2007;3:213
217.
146. Gross H. Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future
prospects.
Appl Microbiol Biotechnol
. 2007;75:267
277.
147. Udwary DW, Zeigler L, Asolkar RN, et al. Genome sequencing reveals complex secondary metabolome in the
marine actinomycete
Salinispora tropica
.
Proc Natl Acad Sci USA
. 2007;104:10376
10381.
148. Gross H, Stockwell VO, Henkels MD, Nowak-Thompson B, Loper JE, Gerwick WH. The genomisotopic
approach: a systematic method to isolate products of orphan biosynthetic gene clusters.
Chem Biol
.
2007;14:53
63.
