Biomedical Engineering Reference
In-Depth Information
Fig. 7.6
Sketch of propagation phase
APC (with the cofactor PS) inhibits both cofactors FVa and FVIIIa, thus
switching off the production of tenase and of prothrombinase. Surviving FIXa, FXa,
FXIa, and thrombin are inactivated by ATIII (this action is greatly accelerated by
heparin), and TFPI complexes with FXa, inhibiting FVIIa-TF at the same time.
The clot has grown to its maximum size and it is now time to take care of its
gradual dissolution, which, however, needs to be delayed. Once more thrombin has
a leading role:
•
(Thr. 7) thrombin activates TAFI, which makes fibrin more resistant to the attack
of plasmin.
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