An Overview of the Options for Antimicrobial Hard Surfaces in Hospitals - Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections - page 151

Ismail
2011
[ 75 ]

London, UK Dental clinic Silicon polymers

+ photosensitiser
methylene blue
(MB) +/

Prospective observational
study. Silicon polymer
coatings supplemented
with either MB only or
MB +Au

Open agar plates and petri
dishes with control and
test coatings placed on a
shelf adjacent to dental
chairs and exposed to the
air for 24 h

Significant mean 55 %
reduction in aerobic
bacteria and mean 71 %
reduction in anaerobic
bacteria on MB +Au
coatings. MB only
coatings had reduced
counts vs. control, but not
statistically significant

Required illumination by a
lamp. In vitro studies
using MRSA on the same
surface types
demonstrated
substantially greater log
reductions (2-4 log)

gold
nanoparticles
(Au)

Leng
2013
[ 109 ]

TiO 2 was sprayed on
following thorough
cleaning. Almost 10 % of
samples grew MRSA.
There was no evidence of
reduced TiO 2 activity
over time. TiO 2 treatment
was not associated with
reduced contamination in
multiple logistic
regression
A&E Accident and Emergency Department, CDA Copper Development Association, CI 95 % confidence interval, CVD chemical vapour deposited, HDU high dependency
unit, ICU intensive care unit, MDR-GNR multidrug-resistant Gram-negative rods, OR odds ratio, PHMB polyhexamethylene biguanide, QAC quaternary ammonium
compound

Singapore ICU and

general
ward

Titanium dioxide
(TiO 2 )

Prospective observational
study. 2/8 ICU single
rooms and four
intermediate care beds
treated with TiO 2 ;
applied to surfaces and
fixed furniture (such as
beds and door handles)

Standardardised sampling
performed 6, 9, 12, 18 and
24 months after
application, combined
with ad hoc sampling
around MRSA-positive
patients. 'Culture-positive'
defined as identification of
MRSA or Gram-negative
rod

Overall, untreated samples
were significantly more
likely to be culture
positive (12 % vs. 4 %)
than treated surfaces. No
significant different in
culture positive rates
from untreated vs. treated
surfaces during ad hoc
sampling (15 % vs. 12 %)