Biology Reference
In-Depth Information
adapted from a paper now in press e L Hood and M Flores; Systems
Medicine and the Emergence of Proactive P4 Medicine: Predictive,
Preventive, Personalized and Participatory; New Biotechnology, in
press. LH would like to acknowledge the support of the Luxembourg
Centre for Systems Biomedicine and the University of Luxembourg,
the General Medical Sciences Center for Systems Biology GM076547
and a Department of Defense contract on Liver Toxicity W911SR-
09-C-0062. NDP acknowledges funding from an NIH-NCI Howard
Temin Pathway to Independence Award in Cancer Research, a Roy J.
Carver Young Investigator Grant, and the Camille Dreyfus Teacher
[18] Kinross JM, Darzi AW, Nicholson JK. Gut microbiome
host
interactions in health and disease. Genome Med 2011;3:14.
[19] Williams A, Smith JR, Allaway D, Harris P, Liddell S,
Mobasheri A. Applications of proteomics in cartilage biology and
osteoarthritis research. Front Biosci 2012;17:2622 e 44.
[20] Janecka I. Is U.S. health care an appropriate system? A strategic
perspective from systems science. Health Res Policy Syst
2009;7.
[21] Christakis NA, Fowler JH. The spread of obesity in a large social
network over 32 years. N Engl J Med 2007;357:370 e 9.
[22] Hood L. A personal journey of discovery: developing technology
and changing biology. Annu Rev Anal Chem (Palo Alto Calif)
2008;1:1 e 43.
[23] Hood L. Acceptance remarks for Fritz J. and Delores H. Russ
Prize. NAE Journal The Bridge 2011;41:46 e 9.
[24] Hood L, Rowen L, Galas DJ, Aitchison JD. Systems biology at the
institute for systems biology. Brief Funct Genomic Proteomic
2008;7:239 e 48.
[25] Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, et al.
Personal omics profiling reveals dynamic molecular and medical
phenotypes. Cell 2012;148:1293 e 307.
[26] Lazebnik Y. Can a biologist fix a radio? Or, what I learned while
studying apoptosis. Biochemistry 2004;69:1403 e 6.
[27] Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K,
et al. An atlas of combinatorial transcriptional regulation in mouse
and man. Cell 2010;140:744
e
e
Scholar program.
REFERENCES
[1] Hood L. Deciphering Complexity: A personal view of systems
biology and the coming of
'Big' science. Genet Eng News
2011;31:131.
[2] Barabasi AL, Oltvai ZN. Network biology: understanding the cell's
functional organization. Nat Rev Genet 2004;5:101 e 13.
[3] Hood L, Heath JR, Phelps ME, Lin B. Systems biology and new
technologies enable predictive and preventative medicine. Science
2004;306:640 e 3.
[4] Patrinos GP, Brookes AJ. DNA, diseases and databases: disas-
trously deficient. Trends Genet 2005;21:333 e 8.
[5] Loscalzo J, Kohane I, Barabasi AL. Human disease classification in
the postgenomic era: a complex systems approach to human
pathobiology. Mol Syst Biol 2007;3:124.
[6] Auffray C, Chen Z, Hood L. Systems medicine: the future of
medical genomics and healthcare. Genome Med 2009;1:2.
[7] Price N, Edelman L, Lee I, YooH, HwangD, CarlsonG, et al. Systems
biology and the emergence of systems medicine. Genomic and
Personalized Medicine: From Principles to Practice 2009;1:131 e 41.
[8] Buell J. The Digital Medicine Revolution in Healthcare. American
College of Healthcare Executives, Chicago 2011.
[9] Garg V, Arora S, Gupta C. Cloud computing approaches to
accelerate drug discovery value chain. Comb Chem High
Throughput Screen 2011;14:861 e 71.
[10] Topol E. The Creative Destruction of Medicine: How the Digital
Revolution Will Create Better Health Care, a Member of the
Perseus Books Group. New York: Basic Books; 2012.
[11] Collino S, Martin FP, Rezzi S. Clinical metabolomics paves the way
towards future healthcare strategies. Br J Clin Pharmacol 2012.
doi: 10.1111/j.1365-2125.2012.04216.x.
[12] Smarr L. Quantified Health: A 10-year detective story of the digitally
enabled genomic medicine. Strateg News Lett 2011;14:1 e 33.
[13] Weston AD, Hood L. Systems biology, proteomics, and the future
of health care: toward predictive, preventative, and personalized
medicine. J Proteome Res 2004;3:179 e 96.
[14] Hood L, Friend SH. Predictive, personalized, preventive, partici-
patory (P4) cancer medicine. Nat Rev Clin Oncol 2011;8:184 e 7.
[15] Tian Q, Price ND, Hood L. Systems cancer medicine: towards
realization of predictive, preventive, personalized and participatory
(P4) medicine. J Intern Med 2012;271:111
52.
[28] Keller A, Backes C, Leidinger P, Kefer N, Boisguerin V,
Barbacioru C, et al. Next-generation sequencing identifies novel
microRNAs in peripheral blood of lung cancer patients. Mol Bio-
syst 2011;7:3187 e 99.
[29] Pinzani P, Salvianti F, Zaccara S, Massi D, De Giorgi V,
Pazzagli M, et al. Circulating cell-free DNA in plasma of mela-
noma patients: qualitative and quantitative considerations. Clin
Chim Acta 2011;412:2141 e 5.
[30] Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as
biomarkers in cancer patients. Nat Rev Cancer 2011;11:426 e 37.
[31] Chapman MH, Sandanayake NS, Andreola F, Dhar DK,
Webster GJ, Dooley JS, Pereira SP. Circulating CYFRA 21 e 1is
a specific diagnostic and prognostic biomarker in biliary tract
cancer. J Clin Exp Hepatol 2011;1:6 e 12.
[32] Matsusaka S, Suenaga M, Mishima Y, Kuniyoshi R, Takagi K,
Terui Y, et al. Circulating tumor cells as a surrogate marker for
determining response to chemotherapy in Japanese patients
with metastatic
e
colorectal
cancer. Cancer Sci 2011;102:
1188 e 92.
[33] Roach JC, Glusman G, Smit AF, Huff CD, Hubley R, Shannon PT,
et al. Analysis of genetic inheritance in a family quartet by whole-
genome sequencing. Science 2010;328:636 e 9.
[34] Chiu CL, Randall S, Molloy MP. Recent progress in selected
reaction monitoring MS-driven plasma protein biomarker analysis.
Bioanalysis 2009;1:847
55.
[35] Yao M, Ma L, Duchoslav E, Zhu M. Rapid screening and char-
acterization of drug metabolites using multiple ion monitoring
dependent product ion scan and postacquisition data mining on
a hybrid triple quadrupole-linear ion trap mass spectrometer. Rapid
Commun Mass Spectrom 2009;23:1683 e 93.
[36] Ma S, Funk CC, Price ND. Systems approaches to molecular
cancer diagnostics. Discov Med 2010;10:531 e 42.
e
21.
[16] Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, et al.
A systems approach to prion disease. Mol Syst Biol 2009;5:252.
[17] Hidalgo CA, Blumm N, Barabasi AL, Christakis NA. A dynamic
network approach for the study of human phenotypes. PLoS
Comput Biol 2009;5:e1000353.
e
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