Biology Reference
In-Depth Information
amyotrophic lateral sclerosis (ALS) [257] ; a yeast model of
A
examples in multidisciplinary, collaborative efforts has the
potential to accelerate the translation of fundamental
research concepts and basic knowledge into direct appli-
cations for the benefit of society [16] . Together with this,
fundamental and practical studies using yeast as a touch-
stone model in post-genomic research are progressively
appearing, with direct applications in biotechnology and
medicine. Relevant selected examples are presented in
Table 18.3 . For more complete information on the latest
toxicity in yeast [258] . In biotechnological processes,
yeasts (e.g., S. cerevisiae, Pichia pastoris) expressing
human wild-type and misfolded (variant) proteins [259] are
being used for the comprehensive characterization of
bottlenecks in recombinant protein production, and of
protein quality control mechanisms and dynamics.
The application of comprehensive yeast systems
biology strategies to the above and more advanced
b
TABLE 18.3
Yeast Systems Biology Advanced Studies and Applications in Human Disease and Biotechnology
Yeast advanced studies and applications
Reference
1) Yeast models for comprehensive Systems Biology studies of dynamics of dysregulated networks in
biotechnology and disease, early detection of imbalances and networks dynamics
[51,240,243,260]
Yeast cell cycle model/design principles
[250] .
Yeast model studies on eukaryotic cell growth (balanced cell growth)
[53,108,117,261,262]
Yeast breast cancer model (yeast with human mutations and increased cell proliferation)
(uncontrolled growth)
[263]
Yeast expressing parasite genes and their human orthologs for protein quality control
networks
studies and identification of antiparasitic agents
[264, 265]
Yeast as a model for aging research studies
[266]
Yeast models of protein folding diseases and human neurodegenerative disorders
[245,257,258,267
272]
e
Yeast industrial strains expressing human wild-type and misfolded (variant) proteins
[259]
2) Yeast molecular, high-throughput Systems Biology studies and applications in
biotechnology and human disease
[16,273]
Yeast functional screen to identify new candidate amyotrophic lateral sclerosis (ALS) genes
[274]
Yeast genetics and metabolic profiling for characterization of human disease alleles
[255]
Yeast-based assay for identification of drugs active against human mitochondrial disorders
[275]
Phenotypic screening for compounds that rescue TDP-43,
a
-synuclein, and polyglutamine
[276]
proteotoxicity in yeast
Humanized yeast-based high-throughput screen to identify small activators for therapeutic
intervention in neurodegenerative diseases
[277]
Yeast high-throughput screen for inhibitors of A
b ₄₂
oligomerization
[278]
Yeast genomics and drug target identification
[279]
Chemical genomic (chemogenomic) profiling. Screenings of targets genes and biomolecules
using yeast as a model
[280,281]
Yeast systems biotechnology
Development of cell factories for production of advanced biofuels
[282]
Systems biotechnology
Recombinant protein production in yeasts
[283]
Yeast genome-scale metabolic networks in metabolic engineering and biotechnology
processes From modules and network models to network responses
[284]
Metabolic engineering and systems biology systems-level approach for engineering of yeast
cell factories
[285,286]
Search WWH ::




Custom Search