Biology Reference
In-Depth Information
[38] Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK,
Wang H, et al. Compound prioritization methods increase rates of
chemical probe discovery in model organisms. Chem Biol
(10):1273 e 83, http://dx.doi.org/10.1016/j.chembiol.2011.07.018 ,
2011;18. PubMed PMID: 22035796.
[39] Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R,
Armour CD, et al. Functional discovery via a compendium of
expression profiles. Cell. 2000;102(1):109 e 26. PubMed PMID:
10929718.
[40] Zhao R, Davey M, Hsu YC, Kaplanek P, Tong A, Parsons AB,
et al. Navigating the chaperone network: an integrative map of
physical and genetic interactions mediated by the hsp90
chaperone. Cell (5):715 e 27, http://dx.doi.org/10.1016/j.cell.
2004.12.024 , 2005;120. PubMed PMID: 15766533.
[41] Weinstein JN, Myers TG, O'Connor PM, Friend SH,
Fornace Jr AJ, Kohn KW, et al. An information-intensive
approach to the molecular pharmacology of cancer. Science
1997;275(5298):343 e 9. PubMed PMID: 8994024.
[42] Lai MH, Bard M, Pierson CA, Alexander JF, Goebl M, Carter GT,
et al. The identification of a gene family in the Saccharomyces cer-
evisiae ergosterol biosynthesis pathway. Gene 1994;140(1):41 e 9.
PubMed PMID: 8125337.
[43] Hueso G, Aparicio-Sanchis R, Montesinos C, Lorenz S,
Murguia JR, Serrano R. A novel role for protein kinase Gcn2 in
yeast tolerance to intracellular acid stress. biochem j (1):255
Comparative and functional genomics (3):216
24, http://dx.doi.
e
org/10.1002/cfg.391 ,
2004;5.
PubMed
PMID:
18629161;
PubMed Central PMCID: PMC2447451.
[51] Blackman RK, Cheung-Ong K, Gebbia M, Proia DA, He S,
Kepros J, et al. Mitochondrial electron transport is the cellular
target of the oncology drug elesclomol. PLoS One (1):e29798,
http://dx.doi.org/10.1371/journal.pone.0029798 , 2012;7. PubMed
PMID: 22253786; PubMed Central PMCID: PMC3256171.
[52] Skrtic M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z,
et al. Inhibition of mitochondrial translation as a therapeutic strategy
for human acutemyeloid leukemia. Cancer Cell (5):674 e 88, http://dx.
doi.org/10.1016/j.ccr.2011.10.015 ,
2011;20.
PubMed
PMID:
22094260; PubMed Central PMCID: PMC3221282.
[53] Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, AoubalaM,
et al. Discovery, in vivo activity, and mechanism of action of
a small-molecule p53 activator. Cancer Cell. (5):454 e 63, http://dx.
doi.org/10.1016/j.ccr.2008.03.004 , 2008;13. PubMed PMID:
18455128; PubMed Central PMCID: PMC2742717.
[54] Hillenmeyer ME, Ericson E, Davis RW, Nislow C, Koller D,
Giaever G. Systematic analysis of genome-wide fitness data in yeast
reveals novel gene function and drug action. Genome Biol (3):R30,
http://dx.doi.org/10.1186/gb-2010 e 11 e 3-r30 , 2010;11. PubMed
PMID: 20226027; PubMed Central PMCID: PMC2864570.
[55] Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA,
Astromoff A, et al. Genomic profiling of drug sensitivities via
induced haploinsufficiency. Nat Genet (3):278
64,
http://dx.doi.org/10.1042/BJ20111264 , 2012;441. PubMed PMID:
21919885.
[44] Bauer BE, Rossington D, Mollapour M, Mamnun Y, Kuchler K,
Piper PW. Weak organic acid stress inhibits aromatic amino acid
uptake by yeast, causing a strong influence of amino acid auxotrophies
on the phenotypes of membrane transporter mutants. eur j biochem/
FEBS 2003;270(15):3189 e 95. PubMed PMID: 12869194.
[45] Klosinska MM, Crutchfield CA, Bradley PH, Rabinowitz JD,
Broach JR. Yeast cells can access distinct quiescent states. genes dev
(4):336 e 49, http://dx.doi.org/10.1101/gad.2011311 , 2011;25.
PubMed PMID: 21289062; PubMedCentral PMCID: PMC3042157.
[46] Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ,
et al. The connectivity map: using gene-expression signatures to
connect small molecules, genes, and disease. Science (5795):
1929 e 35, http://dx.doi.org/10.1126/science.1132939 , 2006;313.
PubMed PMID: 17008526.
[47] Parsons AB, Lopez A, Givoni IE, Williams DE, Gray CA,
Porter J, et al. Exploring the mode-of-action of bioactive
compounds by chemical-genetic profiling in yeast. Cell.
(3):611 e 25, http://dx.doi.org/10.1016/j.cell.2006.06.040 ,
2006;126. PubMed PMID: 16901791.
[48] Magtanong L, Ho CH, Barker SL, Jiao W, Baryshnikova A,
Bahr S, et al. Dosage suppression genetic interaction networks
enhance functional wiring diagrams of the cell. Nat Biotechnol
(6):505
e
83, http://dx.doi.
org/10.1038/6791 , 1999;21. PubMed PMID: 10080179.
[56] Giaever G, Flaherty P, Kumm J, Proctor M, Nislow C,
Jaramillo DF, et al. Chemogenomic profiling: identifying the
functional interactions of small molecules in yeast. Proc Natl Acad
Sci U S A (3):793 e 8, http://dx.doi.org/10.1073/pnas.0307490100 ,
2004;101. PubMed PMID: 14718668; PubMed Central PMCID:
PMC321760.
[57] Lum PY, Armour CD, Stepaniants SB, Cavet G, Wolf MK, Butler JS,
et al. Discovering modes of action for therapeutic compounds using
a genome-wide screen of yeast heterozygotes. Cell 2004;116(1):
121 e 37. PubMed PMID: 14718172.
[58] Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, Martel N, et al.
Genome-wide fitness test and mechanism-of-action studies of
inhibitory compounds in Candida albicans. PLoS Pathog. (6):e92,
http://dx.doi.org/10.1371/journal.ppat.0030092 , 2007;3. PubMed
PMID: 17604452; PubMed Central PMCID: PMC1904411.
[59] Baetz K, McHardy L, Gable K, Tarling T, Reberioux D, Bryan J, et al.
Yeast genome-wide drug-induced haploinsufficiency screen to deter-
mine drug mode of action. Proc Natl Acad Sci U S A (13):4525 e 30,
http://dx.doi.org/10.1073/pnas.0307122101 ,
e
2004;101.
PubMed
PMID: 15070751; PubMed Central PMCID: PMC384780.
[60] Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman JS.
Backup without redundancy: genetic interactions reveal the cost
of duplicate gene loss. Mol Syst Biol :86, http://dx.doi.org/10.
1038/msb4100127 , 2007;3. PubMed PMID: 17389874; PubMed
Central PMCID: PMC1847942.
[61] Musso G, Costanzo M, Huangfu M, Smith AM, Paw J, San
Luis BJ, et al. The extensive and condition-dependent nature of
epistasis among whole-genome duplicates in yeast. Genome Res.
(7):1092 e 9, http://dx.doi.org/10.1101/gr.076174.108 , 2008;18.
PubMed
11,
http://dx.doi.org/10.1038/nbt.
1855 ,
2011;29.
e
PubMed PMID: 21572441.
[49] Lee W, St Onge RP, Proctor M, Flaherty P, Jordan MI, Arkin AP,
et al. Genome-wide requirements for resistance to functionally
distinct DNA-damaging agents. PLoS Genet (2):e24, http://dx.doi.
org/10.1371/journal.pgen.0010024 , 2005;1. PubMed PMID:
16121259; PubMed Central PMCID: PMC1189734.
[50] Tucker CL, Fields S. Quantitative genome-wide analysis of yeast
deletion strain sensitivities to oxidative and chemical stress.
PMID:
18463300;
PubMed Central
PMCID:
PMC2493398.
 
Search WWH ::




Custom Search