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In-Depth Information
H
2
NH
2
N
NH
2
NH
2
NH
2
NH
2
H
2
N
H
2
N
N
H
2
N
NH
2
N
N
NH
2
N
NH
2
N
H
2
N
N
NH
2
NH
2
H
2
N
N
NH
2
N
N
NH
2
H
2
N
NH
H
2
N
H
2
N
NH
2
N
NH
HN
HN
H
2
N
NH
N
H
2
N
NH
O
O
H
2
N
N
NH
2
NH
2
NH
2
NH
2
NH
2
HN
O O
N
N
HN
O
O
NH
2
HN
NH
H
2
N
N
O
O
N
NH
N
O
N
NH
2
O
N
HN
H
2
N
NH
2
H
2
N
H
2
N
NH
N
HN
N
NH
HN
O
N
O
N
NH
O
O
O
NH
O
N
H
2
N
O
N
N
O
NH
NH
2
HN
O
N
N
N
O
N
HN
N
NH
2
O
H
2
N
N
H
2
N
H
2
N
HN
NH
N
N
N
O
N
N
NH
HN
O
NH
O
O
O
HN
H
2
N
N
N
O
N
NH
N
O
HN
O
NH
2
NH
2
NH
2
N
N
O
N
H
N
O
O
N
N
H
2
N
NH
HN
NH
2
H
2
N
H
2
N
N
NH
O
O
O
O
NH
N
N
O
HN
N
N
H
2
N
N
N
O
O
N
N
H
N
HN
O
NH
2
NH
2
N
NH
NH
2
O
O
N
N
N
H
2
N
HN
O
O
N
N
O
N
NH
2
H
2
N
H
2
N
O
O
O
N
H
N
NH
O
N
H
N
H
N
N
O
N
H
2
N
N
N
H
HN
N
O
NH
H
O
N
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
N
O
N
N
H
NH
2
N
H
2
N
N
NH
O
HN
NH
O
N
O
O
HN
O
N
H
NH
2
HN
H
2
N
H
2
N
N
N
O
N
O
O
H
2
N
N
N
N
H
O
N
NH
O
HN
O
N
N
N
NH
H
2
N
O
NH
2
O
O
HN
HN
O
N
O
NH
N
HN
N
H
NH
2
O
NH
NH
H
2
N
H
2
N
H
2
N
N
N
NH
N
O
N
H
NH
N
O
O
N
O
O
H
2
N
HN
N
O
NH
2
O
O
N
HN
O
N
HN
O
NH
NH
N
N
NH
2
NH
2
H
2
N
HN
N
O
N
NH
N
NH
H
2
N
O
N
O
N
HN
N
NH
2
N
O
O
O
HN
H
2
N
N
N
N
O O
NH
H
2
N
NH
O
NH
2
NH
2
N
HN
O
HN
NH
NH
2
N
NH
H
2
N
HN
H
2
N
H
2
N
N
H
2
N
NH
2
NH
2
N
N
H
2
N
H
2
N
NH
2
NH
2
NH
2
N
NH
2
NH
2
H
2
N
H
2
N
H
2
N
H
2
N
NH
2
NH
2
(a)
(b)
16.2
Commercially available G5 PAMAM (a) and G4 PPI (b) dendrimers (adapted with permission from Jang
et al.
, 2009).
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