Effectors of Rab GTPases: Rab Binding Specificity and Their Role in Coordination of Rab Function and Localization - Ras Superfamily Small G Proteins: Biology and Mechanisms 2 - page 53

Table 3.3 Rab:effector affinities
Rab Meth. a Effector K d Reference

Rab1b OCRL (539-901) 3.7 μ M FS Hou et al. ( 2011 )

Rab3a/c/d Rim1/ELKS 1-2 μ M SPR Wang et al. ( 2001 )

Rab4a Rabenosyn-5 (HepR) 6.2 M-

7.7

μ SPR Eathiraj

et al. ( 2005 ) μ M

Rab5 Rabenosyn-5 (C 2 H 2 Zn finger) 0.9 μ M-1 μ M SPR Eathiraj

et al. ( 2005 )

Rab5a Rabenosyn-5 (C 2 H 2 Zn finger) 4.8 μ M SPR Mishra et al. ( 2010 )

Rab5 Rabenosyn-5 (HR2) 2.7 M-

4.6 μ M

μ SPR Eathiraj

et al. ( 2005 )

Rab5a OCRL (539-901) 3.6 μ M FS Hou et al. ( 2011 )

Rab5a EEA1 2.4 μ M SPR Mishra et al. ( 2010 )

Rab6a OCRL(539-901) 3.7 μ M FS Hou et al. ( 2011 )

Rab6a Bicaudal 1.5 μ M FS Bergbrede

et al. ( 2009 )

Rab6a PIST 2.7 μ M FS Bergbrede

et al. ( 2009 )

p150 Glued

2.4 μ M

Rab6a FS Bergbrede

et al. ( 2009 )

Rab6a Rim1/ELKS 16 μ M SPR Wang et al. ( 2001 )

Rab6 GCC185 2.3 μ M ITC Burguete

et al. ( 2008 )

Rab8a OCRL (539-901) 900 nM FS Hou et al. ( 2011 )

Rab9 GCC185 4.5 μ M ITC Burguete

et al. ( 2008 )

Rab11a/b Evi5 55 nM/50 nM SPR Westlake

et al. ( 2007 )

Rab11a/b FIP1/RCP 107 nM/

173 nM

ITC Junutula

et al. ( 2004 )

Rab11a/b FIP2 40 nM/44 nM ITC Junutula

et al. ( 2004 )

Rab11a/b FIP5/Rip11 54 nM/46 nM ITC Junutula

et al. ( 2004 )

Rab11a FIP2 250 nM ITC Lall et al. ( 2013 )

Rab11a FIP3 290 nM FS Eathiraj

et al. ( 2006 )

Rab11a MyoVb 254 nM SPR Pylypenko

et al. ( 2013 )

Rab14 Rabenosyn-5 (HepR) 13 μ M SPR Eathiraj

et al. ( 2005 )

Rab14 Rabenosyn-5 (HR2)/(fl without C 2 H 2

Zn finger)

54 μ M/
9.6 μ M

SPR Eathiraj

et al. ( 2005 )

63 μ M

Rab21 Rabenosyn-5 SPR Mishra et al. ( 2010 )

Rab22a EEA1 14 μ M SPR Mishra et al. ( 2010 )

Rab22 Rabenosyn-5 (HR2) 9.7 μ M SPR Eathiraj

et al. ( 2005 )

Rab24 Rabenosyn-5 (HR2) 10 μ M SPR Eathiraj

et al. ( 2005 )
(continued)