Biomedical Engineering Reference
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membrane remodeling, and, indeed, it has been shown that Arf6 activity is a
prerequisite for the activation of Rho-family GTPases, such as Rac and Cdc42
(Donaldson
2003
). Intriguingly, moreover, it has been pointed out that Arfs are
conserved throughout eukaryotes, and are present in the earliest eukaryotes, such
as
Giardia lamblia
, in which no Ras GTPases nor hetero-trimeric G-proteins are
¼
Show#Evolution
; Kahn
2003
). Formation
of vesicles and their cargo selection, trafficking, and recycling, as well as the
processes of endocytosis and the exocytosis therein involved, are crucial for cell
integrity and function, including neuronal transmission and communication.
Therefore, further studies on the detailed functions and regulatory mechanisms of
ArfGAPs bearing multiple different modules, as well as how the timing of GAPing
is controlled, will definitely push molecular cell biology, as well as medicine and
neuroscience, into new frontiers.
¼
¼
References
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