Small G Proteins: Arf Family GTPases in Vesicular Transport - Ras Superfamily Small G Proteins: Biology and Mechanisms 2 - page 197

vesicles? How exactly are Arf molecules arranged within the coat to allow efficient
uncoating? What is the role of lipid sorting in COPI vesicles? Are lipids also sorted
during formation of COPII vesicles? Are the lipid compositions identical of the
membranes of isoformic vesicles?
Likewise, more general questions are still pending: why do principally different
mechanisms exist of coat recruitment, one step in the COPI, and two steps in the
CCV and COPII systems? To what extent does vesicular transport contribute to
overall membrane transport within a eukaryotic cell? Answers to such questions
will finally help to solve a core question pending now for more than 100 years: why
does the Golgi apparatus possess its characteristic structure, a staple of flat
cisternae?
Acknowledgements The work lab of FTW was supported by the German Research Council
SFB638 project A10 and A16. We would like to apologise to all colleagues whose work could not
be cited due to space limitation.
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