ZBrush as a Character Design Tool - ZBrush Creature Design: Creating Dynamic Concept Imagery for Film and Games - page 36

Strong effects can be achieved by breaking the norms of the proportions of the face or body. For example,
eye spacing has been used to great effect in several recent character designs to break with norms (see Figure
1-35 ) .
Figure 1-35: This figure shows the uncanny effect created by breaking the normal proportions of the face.