Biomedical Engineering Reference
In-Depth Information
and the way in which the interactions cooperate to recognize target molecules in many
molecular imprinted polymer systems is not clearly understood. In addition, many
fundamental properties of the molecular imprinted polymers prepared, such as the
dependence of the affinity on cross-linking agent concentration, functional monomer
concentration, buffer composition, ionic strength, pH, and temperature, have not yet to be
systematically studied. It is evident that the development of the molecular modeling and
analytical techniques will enable the better understanding of the effective molecular imprinted
polymer-based receptors.
It is believed that combined with the increasing interest in creating materials which are
capable of mimicking biological processes, the study of molecular imprinted polymers
capable of the selective recognition of peptides, proteins, and other biological
macromolecules will continuously receive considerable attention in the next decades.
Acknowledgement
This work is supported by National Natural Science Foundation of China (Approval No.
20704019).
References
[1]
O'Mahony, J; Molinelli, A; Nolan, K; Smyth, MR; Mizaikoff, B. Towards the rational
development of molecularly imprinted polymers: H-1 NMR studies on hydrophobicity
and ion-pair interactions as driving forces for selectivity. Biosensors and Bioelectrinics ,
2005, 20, 1884-1893.
[2]
Molinelli, A; O'Mahony, J; Nolan, K; Smyth, MR; Jakusch, M; Mizaikoff, B. Analyzing
the mechanisms of selectivity in biomimetic self-assemblies via IR and NMR
spectroscopy of prepolymerization solutions and molecular dynamics simulations.
Analytical Chemistry , 2005, 77, 5196-5204.
[3]
Nicholls, IA; Andersson, LI; Mosbach, K; Ekberg, B. Recognition and enantioselection
of drugs and biochemicals using molecularly imprinted polymer technology. Trends in
Biotechnology , 1995, 13, 47-51.
[4]
Whitcombe, MJ; Vulfson, EN. Imprinted Polymers. Advanced Materials , 2001, 13,
467-478.
[5]
Quaglia, M; Sellergren, B; Lorenzi, ED. Approaches to imprinted stationary phases for
affinity capillary electrochromatography. Journal of Chromatography A , 2004, 1044,
53-66.
[6]
Wei, S; Jakusch, M; Mizaikoff, B. Capturing molecules with templated materials—
Analysis and rational design of molecularly imprinted polymers. Analytica Chimica
Acta , 2006, 578, 50-58.
[7]
Bossi, A; Bonini, F; Turner, APF; Piletsky, SA. Molecularly imprinted polymers for the
recognition of proteins: The state of the art, Biosensors and Bioelectronics , 2007, 22,
1131-1137.
Search WWH ::




Custom Search